Over my head, and the presenter moves a little too fast, but it had a lot good information. I will have to digest it slowly, looking up terms, etc..
So far, the speaker almost answered two questions I have had for a while:
1) How do the Dendritic Cells tansport the information about the antigen. Ie, do they consume the antigen, and transport it (apparently breaking it down some for presentation) or do they somehow image it... ie make a negative of it's 3D geometry and ionic character...
Apparently they can consume antigens for transport back, but I don't think they always do that. On the tumor cell membrane, if they eat the antigen, it won't be there for the T-Cells to find later. Maybe that doesn't matter because the amplification of the one DC find overwhelms the statistics... but I did not get that yet. And I guess... a related question is how many T-Cells can a single programmed DC program? Probably many... but I don't remember hearing that.
2) The other question is whether the T-Cells can multiply and retain their antigen target programming in the process. He did say that they can multiply, but it was not clear to me whether the new T-Cell keeps the programmed target info. If so, that's a neat trick.
Several Good Links Provided by Flipper lately:
Heavy Duty Genentech Speaker on Immune System:
Dendrion video on Immunotherapy Techniques
Post # 3741 on Northwest's Newer Mfg Facility (not a link)
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