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BonelessCat

01/29/14 12:04 AM

#79240 RE: JG36 #79238

That's because you have no clue regarding the underlying science and the current level of confirmation and confidence in results testing those theories.

You are a lot like one of the FDA guys who gave guidance who after an initial presentation asked the NNVC docs if they had thought of swapping out ligands to instead target the attachment sites on host cells to block the flu particles from attachment. When Diwan asked why would they want to do that if it already attacked and destroyed flu viremia? The FDA guy said that there were already drugs in clinical trials that did that, but there were none that targeted the virus so it was unproven. But he just knew it would work to block entry to host cells.

He didn't get the science because it wasn't neuraminidase based, or it didnt change/interact with the host in some way. He was one of the guys who shaped the guidance toward IND enabling.
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ZincFinger

01/29/14 6:59 AM

#79243 RE: JG36 #79238

Totally wrong. As is so often the case with your statements that one was based on a gross generality with no reference whatsoever to the specifics of NNVC that indicate why the generality is inapplicable.

Almost all generalities have exceptions and many are crude ones that are not all that accurate even when applied to a group **as a whole**. They are only useful at all when applied to **groups** and are often totally wrong when applied to individual cases. You can readily drown crossing a river that's only 18 inches deep. Get it? It's the deviations from the average that are the most important.

NNVC has many factors that strongly support the claim of 90% probability of success and they've been discussed here very frequently and in great detail. Yet you blithely ignore all of it in favor of a gross generality that clearly does not apply.

Very brieflly:

all current anti virals are of both very limited efficacy and of narrow applicability.

NNVC's drugs are, by the nature of their design both highly effective (traps the virus with a receptor that the virus cannot avoid because it MUST use that receptor to infect and the same receptors are used by whole classes of viruses, making the drugs broadly applicable).

I'm really not at all sure how you manage to overlook that.