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Wednesday, January 29, 2014 12:04:40 AM
You are a lot like one of the FDA guys who gave guidance who after an initial presentation asked the NNVC docs if they had thought of swapping out ligands to instead target the attachment sites on host cells to block the flu particles from attachment. When Diwan asked why would they want to do that if it already attacked and destroyed flu viremia? The FDA guy said that there were already drugs in clinical trials that did that, but there were none that targeted the virus so it was unproven. But he just knew it would work to block entry to host cells.
He didn't get the science because it wasn't neuraminidase based, or it didnt change/interact with the host in some way. He was one of the guys who shaped the guidance toward IND enabling.
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