OVERALL the CTs should go FASTER because of the low toxicity.
It may take a few extra weeks at the start for extra animal tests (to determine the appropriate dose for the animal tests. Say WHAT?! You do widely spaced tests across a very broad range of doses so you can "bracket in" the range to focus on with small increments. A few short tests can make the dose selection of the final tests so much better that they take fewer steps. (Similar to artillery fire: the first volley is in broad steps to get the target "bracketed", then the next volley is small steps within the two previous steps on each side so that all the second volley is very close and the third volley, if necessary, hits it.)
Because with very low toxicity the therapeutic dose will be much less than the toxic dose and the initial dose can be a lot closer to the therapeutic dose than with the usual toxicity **AND** the steps between increments of the doses can be larger = fewer steps = less time. [color=red] Those effects combined speed up the overall process much more than the few extra animal steps slowed it down: OVERALL with low toxicity the trials go faster. [/color]PLUS the odds of success are much better because you can get a therapeutic dose well within the range expected to be effective rather than just barely within it as you sometimes have to settle for.
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