Replies to post #7910 on Lightwave Logic Inc (LWLG)

[Rickface]

Thanks X,

That summary sums up the "aromatic advantage" over the BLA type chromophores. Of course, there are always disadvantages as well and to complete the summary I will bring up two.

First, the synthesis of these large aromatic chromophores (Perkinamines) is difficult due to insolubility and high level of aggregation. Fred Sr. was, in my opinion, the worlds leading researcher through the last 30 years in the synthesis of these molecules. It was his constant focus. In fact, all aspects of the chromophore's stability (thermal, photo and temporal) were foundational in his molecular design approaches.

Second, because of the flat nature of the aromatic chromophores, dimerization and aggregation in general are major hurdles that must be overcome. The spacer systems that Lightwave has patented are key to overcoming this disadvantage. Given, the reported activities of 100-300 pm/V for the Perkinamine materials, I believe these spacer systems have been successful in addressing the dimerization challenge.

Rick