Holy crap! Thanks for asking those questions, lit a light bulb in my thick skull - just did some gargling and discovered that Valtrex can cause severe liver stress and elevated enzymes! Makes total sense why my AST/ALT jumped from < 50 to >200, especially given that I've been taking it regularly for months now after developing tolerance to it's side effects - I also believe that increased liver stress is why my TGs jumped from < 200 to >400 *after* I switched to Vascepa in May. The bad news: it was REALLY helping to tamp down the EBV/CFS, now I have to stop to confirm it's the cause - CRAP! I sorta liked not having to sleep until noon every day from lack of energy.....