This is not to say Reduce IT will only be statistically significant in unstable angina as you can see from JELIS the people with CAD history got more benefit than those that did not and as stated it would ave been interesting to follow up long term for mortality.
Reduce It has much sicker individuals than JELIS and thus we will more likely be able to see if the effects of EPA will reduce death and other events. I think it's possible if JELIS study continued and follow up at 10, 15 and 20 years we may have seen a statistically significant reduction in areas other than unstable angina. Hopefully, Reduce It will show this but it cannot be argued that JELIS, at study conclusion, reduced deaths from heart attacks because in Heart Attack and Fatal MI there was no difference in the groups. Then again there were so few of those events in total I just think the healthy population made it impossible for EPA to show any effects in that area as regardless of EPA people in that group were not going to die in any significant numbers within the period of the study. Hopefully this is something Reduce IT can prove with a sicker population.
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