In stereoisomers the bond structure is the same, but the geometrical positioning of atoms and functional groups in space differs. This class includes enantiomers where different isomers are non-superimposable mirror-images of each other, and diastereomers when they are not.
Diastereomerism is again subdivided into "cis–trans isomers", which have restricted rotation within the molecule (typically isomers containing a double bond) and "conformational isomers" (conformers), which can rotate about one or more single bonds within the molecule.
An obsolete term for "cis–trans isomerism" is "geometric isomers".[3] For compounds with more than two substituents E-Z notation is used instead of cis and trans. If possible, E and Z (written in italic type) is also preferred in compounds with two substituents.[4]
Bla Bla........
While structural isomers typically have different chemical properties, stereoisomers behave identically in most chemical reactions, except in their reaction with other stereoisomers. Enzymes however can distinguish between different enantiomers of a compound, and organisms often prefer one isomer over the other. Some stereoisomers also differ in the way they rotate polarized light. http://en.wikipedia.org/wiki/Isomer
So it's likely Vascepa and Lovaza EPA's experience Diastereomerism. (Vascepa cis)ethyl all-cis-5,8,11,14,17-icosapentaenoate and (Lovaza Z)5Z,8Z,11Z,14Z,17Z)-ethyl 5,8,11,14,17-eicosapentaenoate.
E & Z: E-Z notation, or the E-Z convention, is the IUPAC preferred method of describing the stereochemistry of double bonds in organic chemistry. It is an extension of cis/trans notation that can be used to describe double bonds having three or four substituents.
Following a set of defined rules (Cahn-Ingold-Prelog priority rules), each substituent on a double bond is assigned a priority.
If the two groups of higher priority are on opposite sides of the double bond, the bond is assigned the configuration E (from entgegen, German: [?nt'ge?g?n], the German word for "opposite").
If the two groups of higher priority are on the same side of the double bond, the bond is assigned the configuration Z (from zusammen, German: [tsu'zam?n], the German word for "together"). Trans-2-butene.svg http://en.wikipedia.org/wiki/E-Z_notation
=========== Laymans Vascepa and Lovaza EPA sources are from two different molecules structurally & different efficacy at the same target receptors. Both have the same number of double bonds, same molecular formula and same weight weight. They are "shaped" chemically different.
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