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bidrite

05/16/13 9:15 AM

#122497 RE: Protector #122494

<For the rest this abstract is, from where I stand, a disappointing one. It doesn't emphasize the big disadvantage of the Bavi arm vs the Control Arm when it comes to enrolled ECOG 2 patients. >

CP, I think you have to read this PR that just came out this morning

http://finance.yahoo.com/news/peregrine-pharmaceuticals-immunotherapy-bavituximab-highlighted-123000512.html

Notice this quote Abstract Conclusions: In this patient population with extensive disease burdens and limited treatment options

I think they are letting us know that there were significant burdens in the trial and will be highlighted in the actual poster.
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MazelMan

05/16/13 9:18 AM

#122499 RE: Protector #122494

CP

All I have to say is Holy S***.

Thank You for all your DD

D
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Carboat

05/16/13 9:18 AM

#122500 RE: Protector #122494

Quote:
ECOG 2 was 13% in C and 24% in 3 mg/kg B+D arms.

Gamechanger? Given the very small size of the study, how many patients does this 11% actually represent? And interesting that we still have no resolution to the censored issue which is quite a bit more than11% Where is the updated info on this?
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md1225

05/16/13 10:17 AM

#122513 RE: Protector #122494

Cloaked you are GENIUS!!! FTM entdoc KT Thurly Geocap Jakedog r622 RRdog Goodjohn BSPalad our resident brain trust what do you men make of Cloaks rationale!!!

Im a big dumby but I AGREE!
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jakedogman1

05/16/13 10:21 AM

#122514 RE: Protector #122494

the real difference is the difference between other trials ecog status vs ecog comparisons between the bavi trial. the abstract did state that the condition of the patients was pretty bad.
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atonewith PPHM

05/16/13 10:31 AM

#122516 RE: Protector #122494

CP, Thank you for the analysis! You amaze me! As usual, as Spock would say " it is only logical"
I am looking for a surprise soon. Just a gut feeling.
I am buckled in and ready to Wook it up!
AtonewithPPHM
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bidrite

05/16/13 10:41 AM

#122518 RE: Protector #122494

CP - that was my initial reaction as well after reading the abstract. As much as I want it to be true, do you believe these abstracts were written at some point during Q2? It was my understanding that they were submitted months ago, prior to an FDA meeting.


<However, it is the un-smoothed use of the words "and is the planned" that interests me. It is unlike Peregrine to use such clear wording. One could have expected "and is a possible or probable candidate for PIII!">

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freethemice

05/16/13 10:48 AM

#122519 RE: Protector #122494

The information on the ECOG status was announced back on Sept 7th. Nothing new there.

Now this is a game changer! We have NEVER in the past had this information unless I am mistaken


The new control arm has 10/80 = 12.5% with ECOG PS=2.