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DewDiligence

11/20/12 3:57 PM

#152783 RE: mcbio #152780

Behçet’s uveitis is a small orphan indication; however, XOMA/Servier’s phase-3 program in uveitis includes the much larger market for non-infectious uveitis (NIU)—see #msg-80192133.
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genisi

11/21/12 5:54 AM

#152815 RE: mcbio #152780

I amuse I'm stating the obvious here but that pilot XOMA's trial was an open, uncontrolled, in 7 patients only, in Turkey (http://ard.bmj.com/content/71/4/563.abstract).
For the sake of comparison, this is AMGN's Kineret (a different anti IL-1 antibody, which is behind XOMA in Behçet’s disease) pilot trial - randomized, controlled, in 25 patients in US:

http://clinicaltrials.gov/ct2/show/NCT01441076?term=Beh%C3%A7et%E2%80%99s+uveitis&rank=9

Although data from that pilot study are good, I somehow get the feeling of rushing into phase III.