Replies to post #91877 on Avid Bioservices Inc (CDMO)

[RRdog]

Entdoc,

Completely agree with your ideas about "radiation".

Thorpe at NYAS was very clear in private Q and A that he thought radiation was "far" more effective in exposing PS to the cell surface than any chemo.(BTW--of the chemo he felt the best was doxy)

IMO some form of combo with Bavi and radiation would radically affect the discussion on "dosing". Heretofore, dosing at 1mg or 3 mg is not making a "major" difference. Perhaps, this is because there is only limited (sub optimum) PS being exposed using chemo. If a great deal more PS were exposed using radiation, then the "dosing" issue might become much more important.

One would hope that any "oncology" partner would want to spend serious research dollars in this area or that PPHM will get enough up front dollars to pursue it properly themselves.

Best Regards,
RRdog

[spankyvol]

Entdoc... irradiation.


I kept waiting for them to say Bavi may work even better here vs chemo by exposing more PS but they never did that I heard.


Entdoc quote:

FTM, you ask, "Any other ideas?" Lots. Start with Bavituximab + irradiation therapy. This is an indication that should have been the beginning...the opening salvo...of Bavi ued in combination therapy. IMO it was an error to have begun clinical trials with chemo + Bavi, and nothing short of a miracle that it shows significant activity against horrendous disease (metastatic lung cancer). But at the time, with its desperate fiancial situation, chemo trials in India and Russia were the only straw we could grasp. There are so many advancements in specific targeted irradiation now. What an opportunity in virtually every cancer treated with irradiation. Next? Bavi plus surgery. Bavi in less advanced cases? Bavi w. radioactive iodine (as in PPHM's RAI bearing MAB Cotara). And as mentioned before this week, since Bavi can cross the nasal mucosa, a preventive in the form of a nose spray? The price drop today speaks volumes for what the wall street crowd must do to put food on the table.