Replies to post #142309 on Biotech Values

[DewDiligence]

I find the disambiguation of terminology based on normal vs abnormal function to be more useful than the one based on the arbitrary 1% frequency of the least common allele. As your citation in #msg-75807204 notes with respect to the sickle-cell gene, classifying by function is not entirely clear-cut; however, normal vs abnormal function would seem to provide a reasonable workable definition for the terminology in almost all cases without the need for employing an arbitrary frequency threshold.