Replies to post #139449 on Biotech Values

[hptaxis]

Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature 2012;483(7391):531-3. http://www.nature.com/nature/journal/v483/n7391/full/483531a.html

C. Glenn Begley and Lee M. Ellis propose how methods, publications and incentives must change if patients are to benefit.


EDITORIAL: Must try harder. Nature 2012;483(7391):509-. http://www.nature.com/nature/journal/v483/n7391/full/483509a.html

[DewDiligence]

Re: Scientific “discoveries” that don’t stand up to scrutiny

A bookend to your post (from 2007) is in #msg-22859747. (Also see PGS’ reply in #msg-22872587.) Regards, Dew

[poorgradstudent]

Re: Bad Science

With NIH grant funding now at 8-12% levels depending on the institute, this problem is only going to get worse.

[DewDiligence]

In the aggregate, which are a bigger problem for society: flawed studies, or useless studies? An example of the latter:

http://www.reuters.com/article/2012/03/29/us-postpartum-idUSBRE82S16N20120329

Postpartum Depression Tied to Domestic Violence

Mothers with postpartum depression are more likely to be in a violent relationship than moms without depression, and new mothers in abusive relationships are more likely to suffer postpartum depression, according to a new survey of women with infants.

[iandy]

Analysis: Open-access R&D one answer to drug industry woes

http://www.reuters.com/article/2011/09/28/us-pharmaceuticals-research-idUSTRE78R3RP20110928

This might have been previously posted but is germane to the issue.