Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature 2012;483(7391):531-3. http://www.nature.com/nature/journal/v483/n7391/full/483531a.html C. Glenn Begley and Lee M. Ellis propose how methods, publications and incentives must change if patients are to benefit. EDITORIAL: Must try harder. Nature 2012;483(7391):509-. http://www.nature.com/nature/journal/v483/n7391/full/483509a.html