Replies to post #73328 on Avid Bioservices Inc (CDMO)

[FreeNorth]

PS is a body own substance that when exposed on the outside of a cell keeps the immune system from cleaning up that damaged/infected cell.

No, PS on the outside of a cell causes its removal by phatocytes. See for example this article

July 1998, Volume 5, Number 7, Pages 551-562
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Review
The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
Valerie A Fadoka, Donna L Bratton, S Courtney Frasch, Mary L Warner and Peter M Henson

Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206 USA

aAuthor for correspondence: tel: [phone] fax: [phone] email: [e-mail]


Edited by M. Piacentini
Abstract

Exposure of phosphatidylserine on the outer leaflet of the plasma membrane is a surface change common to many apoptotic cells. Normally restricted to the inner leaflet, phosphatidylserine appears as a result of decreased aminophospholipid translocase activity and activation of a calcium-dependent scramblase. Phosphatidylserine exposure has several potential biological consequences, one of which is recognition and removal of the apoptotic cell by phagocytes.