Avid Bioservices Inc (CDMO)

[Protector]

FreeNorth, it is not like that.

Since the exposure of phosphatidylserine on a cell's surface flags it as apoptotic to the immune system and needing removal, what additional benefit does Bavituximab add to the removal of the cell?

PS is a body own substance that when exposed on the outside of a cell keeps the immune system from cleaning up that damaged/infected cell. PS, under normal circumstances, is only present in the Body at the inside of the cell membrane. Bavi binds with one arm to the PS and on the other side advertises something the immune system will want to clean-up. In this way it keeps PS from protecting the cell from clean-up.

If PS is exposed on blood vessels to tumors (vessels that should not be there in the first place and have little cell cracks) it also results in these vessels left alone unless Bavi binds also to that PS to attract the immune system.

Finally, viruses that enter a cell to get replicated in the kernel (where the DNA is and where RNA replication can take place) cannot get there without passing the cell's membrane and be marked with PS as a result. So Bavi will also bind to the PS on those viruses and the immune system will clean them up as-well.

How well Bavi works for a given viral condition depends on the type of cell and viral interaction. Some cells kind of explode (burst) because so many viruses are reproduced that the cell can't hold them, some, as described on the Peregrine pages, see a virus come in and leave to go to the next cell (well go! a virus is not a living thing, it's a string of DNA with or without envelope). All now depends how many where in contact with PS. Bavi may work better in the second scenario then in the first (bursting cells) because in the first many viruses may come in circulation without PS and therefore keep ahead in infecting other cells. This would look like a kind of latency (which probably was observed in the Military Contract). In the case of Ebola for instance this latency is not acceptable for us because Ebola acts very fast (1 week incubation and about max 72 hours before death - internal bleeding).

Subject for the real scientists to correct.