Replies to post #132695 on Biotech Values

[zipjet]

Interesting that cabo shows activity in two different osteotropic cancers - breast cancer metastases are usually osteolytic, and prostate cancer metastases are usually osteoblastic.

I couldn't have said it better.

LOL

ij

[iwfal]

EXEL -

Interesting that cabo shows activity in two different osteotropic cancers

Suggest taking some care with fact that it showed effect on serum NTx in BC patients. Did they publish data on NTx effect in patients without bone mets? (They HAVE published, apparently tangentially, the CTx data from PC patients without bone mets and the curves are essentially the same as CTx in PC patients with bone mets.)

PS There is no question the drug effects bone scan intensity in RA. Not a huge amount - but observably.

PPS In some ways the fact that it does not have the same dramatic effect on BC bone mets as it does on PC bone mets adds to the credibility that the PC bone met effect is real IMO.