peregrinnepickle, I have been taking PAZ for a couple of years now. I have had 3 semiannual physicals with blood work. I have not seen any significant increase in HDL nor reduction in total cholesterol over this time period. In fact my last blood work showed an increase in Total and LDL while HDL remained the same.
My doctor says that my low HDL (between 35 and 43 for the past 15 years) is hereditary and there is really nothing we can do about it short of drugs (and he's not sure that drugs will raise my HDL). I exercise regularly and eat a very high fiber low cholesterol diet but my numbers remain borderline both LDL and HDL as well as Triglycerides. Since my BP is 120/60 and my resting heart rate is 60 or less and all my other blood work is normal, he is not recommending drugs.
You mentioned the interaction of LDL and Total. The formula for LDL is:
LDL=Total-HDL-Tri/5
As HDL goes up LDL goes down but also notice as Tri go up LDL also goes down. I'm not sure that medical science has a complete and accurate handle on how this all works, even with all the trials and testing they have done. It seems like the bench-mark numbers change every six month or so.
For me the benefits of PAZ were; more energy, not as sore after intense workout, sleeping through the night without having to get up every 2 hours to pee, and the biggest thing we noticed in the blood work was an 80% increase in my platelet count.
Willy