2DAA Protocols - Why did VRUS data show better 14 day viral load for single DAA for 1 week followed by 2 DAA in second week?
Perhaps the first drug impairs viral such that it is more receptive to the second drug. Just a theory.
(!!)Assuming the apparent effect is real(!!) (at this point a small dataset but nonetheless a reasonably sized effect) my speculation is that the effect is a result the following:
1) That replication is not immediately halted even in un-resistant strains - thus allowing a strain resistant to one drug but not the other to exist long enough under a dual treatment to cross breed with a strain with the inverse phenotype.
The interesting thing about this would be that how long you do treatment with one drug before starting the other will depend upon how soon you expect breakthroughs to start happening. Which, in turn, would be dependent upon the specificas of the drug and the patient population (among other things).
Also note that it is possible that the BMY drugs could do substantially better if they were protocoled the same way.
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