Replies to post #95252 on Biotech Values

[DewDiligence]

IDIX ReadMeFirst

[Updates:
revised table of major shareholders;
new version of “HCV: Most Likely to Succeed.”]


What is IDIX’s business all about?
IDIX’s drug portfolio
#msg-49736882 Transcript of 1Q10 conference call
HCV primer from IDIX website


Valuation and finances
#msg-49729060 1Q10 financial results
#msg-49729792 Liquidity and cash usage
#msg-49053469 Musings on valuation/exit strategy (4/16/10)
#msg-49457770 Thomas Weisel raises price target to $9 (4/26/10)
#msg-49147564 Wedbush raises price target to $7 (4/19/10)
#msg-49743057 Milestone payments from GSK
#msg-35740500 Tyzeka royalty stream worth ~$25M
#msg-49569765 Latest financing transaction
#msg-49785732 Share count for valuation purposes


News flow
#msg-49733218 2010-2011 news flow


Officers, directors, and major shareholders
#msg-49743604 Composition of Board of Directors
#msg-48436375 Tamar Howson fills open seat on BoD
Capsule résumés of executive officers (click on a name)
#msg-37998991 NVS, IDIX revise terms of relationship
#msg-49997072 Largest shareholders include NVS and GSK
#msg-49785817 Chronology of NVS’ equity stake
#msg-46731440 Current insider shareholdings
#msg-44704472 Recent insider transactions


HCV program: Economic rationale and competition
#msg-50045106 HCV: Most Likely to Succeed (IMHO)
#msg-42717806 GILD’s action on GS9190 may be bullish for IDIX
#msg-38956178 HCV market forecast from Decision Resources
#msg-40127105 Up-front payments of HCV partnerships
#msg-29018192 Prevalence and incidence of HCV in the US
#msg-30190435 Devastating risk of undertreating HCV
#msg-34694166 US prevalence of genotypes 1a and 1b
#msg-34797714 Annual sales of ifn-alpha drugs
#msg-36780163 Musings on combining agents from different classes
#msg-48546028 Musings on combination therapy vis-à-vis NVS
#msg-34925415 Interferon and the Law of Diminishing Returns


HCV program: IDX184 nucleotide polymerase inhibitor
#msg-49003061 Interim phase-2a data look very nice! (table)
#msg-49096739 Interim phase-2a data look very nice (PR)
#msg-49731578 All-oral cocktail of IDX184+IDX320 (1)
#msg-49732533 All-oral cocktail of IDX184+IDX320 (2)
#msg-49115388 Why nucleotides are better than nucleosides
#msg-39719159 Phase-1b monotherapy data
#msg-49055353 Replicon data in combination with other IDIX drugs (1)
#msg-47954632 Replicon data in combination with other IDIX drugs (2)
#msg-43046863 NVS declines to license IDX184
#msg-43102142 Musings on NVS’ decision (dewophile)
#msg-49116246 Possible IDX184 interest by Roche (1)
#msg-49123150 Possible IDX184 interest by Roche (2)
#msg-26915921 How IDX184 is unlike NM283


HCV program: IDX320 protease inhibitor
#msg-45598790 Rationale for IDX320 program
#msg-49731578 All-oral cocktail of IDX184+IDX320 (1)
#msg-49732533 All-oral cocktail of IDX184+IDX320 (2)
#msg-49055353 Phase-1 PK and drug-interaction data
#msg-47954632 Replicon data in combination with other IDIX drugs
#msg-36600884 Musings on selectivity of HCV PI’s


HCV program: IDX375 non-nucleoside polymerase inhibitor
#msg-45350536 Initial data from phase-1 SAD study
#msg-49055353 Replicon data in combination with other IDIX drugs (1)
#msg-47954632 Replicon data in combination with other IDIX drugs (2)
#msg-37246670 EASL 2009 press release
#msg-34334563 Blurb on IDX375 from hivandhepatitis.com


HIV program
#msg-49276920 The New Battle Lines in HIV
#msg-35391933 IDIX, GSK ink IDX899 collaboration
#msg-43254006 GSK/PFE launch ViiV Healthcare
#msg-49507158 IDIX receives $6.5M milestone from GSK (4/23/10)
#msg-49743057 Remaining IDX899 milestone payments from GSK
#msg-49687153 Sustiva (which IDX899 might supersede) sells $1.3B/yr
#msg-47558107 Design of IDX899 phase-2b trials
#msg-48915175 How GSK is planning for a “nuke-sparing” trial
#msg-49282477 Why GSK is planning for a “nuke-sparing” trial
#msg-37495719 Anticipated duration of a phase-2b trial
#msg-44790049 PK/food trial
#msg-31925486 Phase-1/2 IDX899 monotherapy data (PR)
#msg-31944395 Phase-1/2 IDX899 monotherapy data (chart)
#msg-46084532 IDX899 paper in Curr Opin Investigational Drugs
#msg-45984817 HIV market data from GILD’s 4Q09 CC
#msg-35674369 HIV market overview (2007 article from CNNMoney)
#msg-34894135 Musings on Truvada’s patent status
#msg-31175781 HIV incidence in US is higher than previously thought
#msg-31419107 Increased HIV screening will expand market
#msg-33124429 New guidelines to recommend earlier treatment (1)
#msg-36745396 New guidelines to recommend earlier treatment (2)
#msg-37210627 Half of untreated US carriers are in 350-500 CD4 range
#msg-29985830 Design of a late-stage HIV trial


Reference links
http://www.idenix.com/hepc/about
HCV drugs on market and in development
HIV drugs on market and in development
http://www.hivandhepatitis.com