Replies to post #44378 on Avid Bioservices Inc (CDMO)

[Robert C Jonson]

Remember, I am just a lay person trying to translate what I have heard from a few scientists working in this area.


And I, as well as others, appreciate your explanation of Bavi's action, which is lucid and concise. I can only hope that the second explanation you've heard about the ps's being different for normal and abnormal cells is the correct one. Otherwise, we might run into BIIB/ELN's problem with Tysabri where continued use in some people (appears) to cause PML.

[entdoc]

Firefox, you said, "I am just a lay person..." What is your field of expertise? You seem to have an extraordinary grasp of the principles involved here, and powerful, concise expression with the pen.
Possibly one of the more important concepts, elegant in its simplicity, is that cancer treatment is aimed at destroying living, but abnormal cells, using several different strategies, and most cancer treatments (except "healthy living") are "pulsed," such as chemo- or irradiation, in order to allow the healthy organism surrounding the tumor to recover. More specific treatment (MABs) allow less tissue damage (apoptosis) for a crippled immune system (macrophages)to clean up...in addition to fighting the cancer. That's what makes the strategy of more effective/specific MAB delivery systems so compelling. There will doubtless be side-effects and complications with Bavi-, but it appears they will be small in comparison to other modalities (ie, chemo, irradiation, and surgery...or Avastin).