Avid Bioservices Inc (CDMO)

[Fire Fox]

Good point. I have received two types of answers when asking the question you raise.

The first answer has to do with the speed at which the body's street sweepers (i.e. macrophages cells, etc) clean up normal apoptotic cells,. (Apoptosis is simply a fancy word for normal cell death.) Part of the clean up and elimination work of normal apoptosis is done by adjoining cells as well as by circulating macrophage. The net effect is that cells which are in the process of dying a normal death get swept away very quickly, even before the cell membrane disintegrates and releases the stuff inside that would cause chaos if it went circulating in the blood.

The second answer I've heard has to do with the fact that the PS exposed on healthy cancer cells and virons seems to be of a somewhat different character than the PS exposed on dying apoptotic cells.

Truth be known, all of the PS work being done today is very new and there are still many questions, like the one you asked, where they are still doing work to understand better what is going on at the molecular level. All they know for sure is that it is now an empirical fact, from both clinical and pre-clinical studies, that Bavi does not interfere with normal cell apoptosis.

Remember, I am just a lay person trying to translate what I have heard from a few scientists working in this area.