Year 1/2-life Particle ProductIntroduced Indication Radioisotope (days) Range (mm) Metastron 1993 Cancer bone pain Strontium-89 50.6 8.00 Quadramet 1997 Cancer bone pain Samarium-153 1.9 3.00 Bexxar 2003 NHL Iodine-131 8.0 2.00 Zevalin 2003 NHL Yttrium-90 2.7 12.00 Alpharadin phase-3 HRPC bone mets Radium-223 11.4 0.04