Let's see if I understand.
On March 17, AVAN did a reverse split. Their stock was trading at 63 cents.
On April 17, AVAN announced a partnership with Pfizer that provided $40 million upfront, milestone payments and royalties for a possible $390 million total.
On June 2, AVAN received an enormous amount of publicity when they announced doubling survival in some brain cancers.
So, split adjusted the AVAN pps went from $.63 to $1.49 in just 2 1/2 months.
Yep, it must have been the reverse split that caused it.