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rancherho

12/18/07 11:22 PM

#5252 RE: iwfal #5250

Since the powering calculation for Vital 1 would have been done in early 2004 prior to commencing enrollment, your lower estimate of the powering would correspond to their diminished expectations at that point as compared to the subsequent estimates based on Ph 2 results, which your earlier and higher powering estimates, I understood,were based on the later 2007 inputs that I provided.