Replies to post #4658 on GTC Biotherapeutics (fka GTCB)

[n4807g]

Since I donate blood regularly and have to answer all those questions, I've often wondered how many people give blood but don't answer truthfully? My wife was given a transfusion of whole blood three times. On the third transfusion she had a SEVERE, and I mean SEVERE reaction....nurses rushing about like chickens with their heads cut-off. After everything had calmed down I asked the nurse what happened, and she said your wife had an allergic reaction to the blood. I said really, and she said it happens frequently. How safe is the blood supply?

[Pre_Clinical]

So lets recap. You are warning about problems with purifying proteins from milk. I then brought up that there are also problems from CHO cells. I bought up CHO cells because that is a production system of wide usage right now. You responded by trying to raise fears (unrealistic in my book) about herd contaminations. I responded that the goats are in a very controlled environment and that you have greater risks from public contact from humans in closed spaces. Where are you going to get your proteins from?

I am trying to figure out what your problem is, assuming you are not simply a fear mongering short. I also stated that compared to purifying proteins (including rATIII) from pooled human blood, GTCB's approach is far superior and safer. Do you disagree and think that it is safer to purify from blood? Here are the choices, ATIII from pooled human blood or purified from goats milk.

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What's there to recap? You originally made a completely unsubstantiated claim that the production of recombinant proteins in CHO cells carries the same risk profile as transgenic milk protein production. That is a distortion of reality and correpsonds to the contribution of a disservice to this board. Therefore I told you that you were full of crap. There's your recap, bud.