Replies to post #705833 on NorthWest Biotherapeutics Inc (NWBO)

[exwannabe]

.. what is potentially at worst an excellent treatment ...

And therein lies the issue.

They ran a randomized trial where 233 patients received DC-L and 99 received placebo. The 233 did no better than the 99. Not on either PFS nor OS. That is far from an excellent treatment, it is more like grape fruit juice.

Longs can say but, but, but all day long. But reality is approval based on the P3 looks very questionable.

Even if DC-L does work (which I think is possible, but not clear), the value is not much if they have to run another trial. And neither of the combo trials that longs want to hype will do the trick.

[Nemesis18]

>> at best a potential cure for many patients upwards of 50% or higher for GBM <<

That's not what the P3 'cut n paste' trial data showed though is it, for this -cough- 'vaccine' ?

[Hopeforthefuture3]

Where do you get the 50% cure figure for gbm? The trial has 13% long term (5 year) survivors. The trial including poly-iclc had 4 gbm cases and the one with longest survival did not include the adjuvant

[Karlchen]

"......Define a reasonable price......." you ment SP and i agree. Well nobody knows exactly
when (years)
or SP (dollars)
but if i reiterate: "some" years until 10/20 dollars, a decade (or two) 100 to 500 dollars is a fair bet, . . . . IF . . . . . our real potential is as good as we all anticipate.

What i thought while reading your first sentences, you ment what price for the treatment is fair, considering the
RESULT(S):
- living longer
- much longer
- no death for up to 60% of patients, even more with adjustments and combinations within the next years.
- no side effects (cost of treatment)
- no (or less) rediation, chemo and the like
just to name a few, the estimated price without flashwork of about 200.000 dollars is reasonable and will be covered by most insurance around the world if . . . IF it takes longer, much longer for flashworks (worst case, which i don't believe, anyway)

Also to consider: according to supply restraints (in general and specifically the artisan way) there won't be that much patients per insurance companies to handle / 💰.

Very pragmatic, i know, but how it exactly will be, nobody knows . . . . .