One quibble -- I wouldn't say that ADL is not compromised at all in early AD, but that it's not enough to get to a statistically significant result. After all, slightly impaired cognition can be detected.
Alzheimer's Patients ADLs: The same with my Mother. She was allowed to stay by herself in her own home for the first 4 years or so after we knew she had Alzheimer's. I did have an experienced caretaker there at least 8 hours a day with her. Plus meals, A Nurse a couple times per week. After that my wife and I moved her into our home. And kept the caretaker and nurse as well. Her last couple years with us... sometimes I was ME... sometimes I was "My Dad" who had passed away some 15 years prior. And sometimes she would complain to my wife THAT THING YOUR MARRIED TO HE HAS TO GO. Yet some days or parts of days she was near normal as to memory as to who is who. It is a truly terrible disease. So yes no question about it ADL's for early patients make no sense at all.
Now you know why I am here. I searched all the early stage drugs back in 2015 in trial mode and picked Anavex to be the winner. John k9uwa
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