Xena, Thanks. It looks like NAC is involved in many key functions. Checking my own daily supplement (a whole food type vitamin), it has 150 mg of N-Acetyl-L-Cysteine and L-Cysteine. As with most supplements, it's probably best to not over do it.
>>> Acetylcysteine, also known as N-acetylcysteine (NAC)
Side effects
The most commonly reported adverse effects for IV formulations of acetylcysteine are rash, urticaria, and itchiness.[22]
Adverse effects for inhalational formulations of acetylcysteine include nausea, vomiting, stomatitis, fever, rhinorrhea, drowsiness, clamminess, chest tightness, and bronchoconstriction. Although infrequent, bronchospasm has been reported to occur unpredictably in some patients.[40]
Adverse effects for oral formulations of acetylcysteine have been reported to include nausea, vomiting, rash, and fever.[40]
Large doses in a mouse model showed that acetylcysteine could potentially cause damage to the heart and lungs.[41] They found that acetylcysteine was metabolized to S-nitroso-N-acetylcysteine (SNOAC), which increased blood pressure in the lungs and right ventricle of the heart (pulmonary artery hypertension) in mice treated with acetylcysteine. The effect was similar to that observed following a 3-week exposure to an oxygen-deprived environment (chronic hypoxia). The authors also found that SNOAC induced a hypoxia-like response in the expression of several important genes both in vitro and in vivo.
The implications of these findings for long-term treatment with acetylcysteine have not yet been investigated. The dose used by Palmer and colleagues was dramatically higher than that used in humans, the equivalent of about 20 grams per day.[41] In humans, a much lower dosages (600 mg per day) have been observed to counteract some age-related decline in the hypoxic ventilatory response as tested by inducing prolonged hypoxia.[42]
Although N-acetylcysteine prevented liver damage in mice when taken before alcohol, when taken four hours after alcohol it made liver damage worse in a dose-dependent fashion.[43] <<<
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