Replies to post #252210 on Biotech Values

[mouton29]

Just saw iwfal's reply to the same post, and I concur that a sham non-injection may not be adequately masked to the patient.

As it turns out, there is at least one study exploring this and it draws a distinction between trials where one eye is treated vs. trials where both are treated -- in the later it is easier to fool the patients.

In summary, this study has demonstrated that a sham intravitreal injection can successfully mask study participants to treatment group assignment when a detailed procedure is followed which attempts to carefully mimic a true injection procedure. Masking may be less successful when one eye receives real injections and the other eye receives sham injections or an individual eye receives both real and sham injections.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531882/pdf/nihms408013.pdf