Biotech Values

[DewDiligence]

Previously, sham injections were done on an anesthetized eye by pressing an injector with no needle against the eye. For masking purposes [such] an injection…would be an option.

With such a protocol, you can achieve triple masking (patient + investigator + outcome assessor) but not quadruple masking (triple masking + surgeon). Whether this distinction is material to the integrity of a trial is open to question.

Edit: Just saw iwfal's reply to the same post, and I concur that a sham non-injection may not be adequately masked to the patient.