Replies to post #692419 on NorthWest Biotherapeutics Inc (NWBO)

[manibiotech]

Agree

I have stated here before using combination of two approved drugs to treat a condition is done all the time by MDs for various diseases from simple to complex . It doesn’t require approval . Only thing it may require sometimes is coverage by insurance company for expensive options . But some here like to read anything that’s happening on the planet has something to do with NWBO

[exwannabe]

Poly-ICLC is already an approved drug

Still waiting for anybody to find any RA that lists Poly-ICLC (Hiltonol, polyinosinic-polycytidylic acid) as an approved drug. I can not find it on the FDA, EMA or MHRA websites.

The FDA does note that Hiltonol has orphan designation, but is not approved.

The Oncovir website explcitly states it as an experimental;

We promote Hiltonol® as an experimental viral mimic and broad activator of innate and adaptive immunity. We have partnered extensively with both commercial companies and academic institutions.

Oncovir manufactues GMP grade clinical material for use in approved regulatory settings and preclinical material suitable for preclinical and scientific exploration

[dstock07734]

bio,

IMO, the massive hiring and construction of massive manufacturing facilities from BPs has little to do with mRNA.

Take a look the number of trials on cancers run by Moderna. There is only nine. Has Moderna found all the neopeptides that can trigger anti-tumor immune response? I guess not. Otherwise, Moderna would not come to a company which has the patent on neopeptides. Have we seen that GRTS who claimed their neopeptide based technology is superior to Moderna's had rather mediocre results from their GBM trial?

Everyone is entitled to his/her own opinions. The uttermost thing is that we have conviction in the science, LP and the company, and we all are ready to embrace the huge success of the company.

https://trials.modernatx.com/search-results/?SearchTerm=cancer&Latitude=&Longitude=&LocationName=&conditions=&Status=&phases=&AgeRanges=&gender=&GenderDescriptions=&StudyTypes=&AttachmentTypes=&MileRadius=100&PageIndex=0&hasResults=&isHighValue=&SortField=&SortOrder=

[VikingInvest]

Agree Bio. All the buildouts and hiring by BP has absolutely nothing to do with NWBO. It has everything to do with the race for immune therapies like the DCVax platform that these companies are slowly waking up to.

[learningcurve2020]

Perhaps MHRA will consider running a PIP trial in combo as a confirmatory.


There seems to be some evidence it also works on its own.

>>and understood to be basically an adjuvant compound.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356196/