Replies to post #459134 on Anavex Life Sciences Corp (AVXL)

[georgejjl]

Well, it seems that people with schizophrenia taking KarXT may have to take that treatment for one year or more.

"... KarXT demonstrated a favorable long-term metabolic profile where most patients experienced stability or improvements on metabolic parameters over 52 weeks of treatment

A majority of patients (65%) experienced reductions in weight over the course of the trial, with a mean weight decrease of 2.6kg observed at one year...."

https://news.bms.com/news/details/2024/Bristol-Myers-Squibb-Presents-New-Pooled-Interim-Long-Term-Safety-and-Metabolic-Outcomes-Data-from-the-EMERGENT-Program-Evaluating-KarXT-in-Schizophrenia-at-the-2024-Annual-Congress-of-the-Schizophrenia-International-Research-Society/default.aspx

Good luck and GOD bless,

[falconer66a]

Anavex 3-71 Treatment Periods Need to be Determined

Question is how long does a [schizophrenia] patient have to stay on it.

Good question.

Ideally, a patient takes a curative drug only so long as it is needed. After a period of treatment, will Anavex 3-71 permanently terminate the causes of schizophrenia symptoms, or, will the drug be needed chronically, continuously, as in the case with insulin for diabetics?

If 3-71 can produce persisting, on-going therapeutic results after a specific treatment period, wonderful. Hope that proves out. But more likely the root causes of schizophrenia are genetic or biochemical anomalies that persist, which can’t be ultimately fixed by 3-71. Most likely, treatments will require chronic, persisting dosings.

Perhaps after a treatment period, dosings and dosages can be reduced to a low maintenance level. We won’t know until proper clinical trials are run to determine these matters.

[georgejjl]

Tredenwater2,

You calculated a potential worldwide market for Anavex 3-71 for the treatment of schizophrenia of 240 Billion per year.

Good luck and GOD bless,

[mrplmer]

3 million in US 1% of population.

[georgejjl]

tredenwater2,

What do you think now about Anavex 3-71 and the treatment of schizophrenia?

Good luck and GOD bless,