Kiwi, first off, I just picked kidney disease at random, as an example. I don't know much about it, to be honest.
As far as buyout estimates, I am clearly working with a lot of unknowns. I have no idea what revenues will look like eventually. But I look at what has happened in the U.S., Canada, Spain, etc. to help predict what would be "easily achievable". I also don't know what hurdle rate a BP would apply to Amarin revenues. Generally, with less clarity and more risk, a higher hurdle rate is used. With more certainty and less risk, a lower rate can be applied. This is why Denner would never sell today - there's just too many unknowns sitting out there for Amarin. I think once they can get Italy and France on board, get greater traction in UK and China, and possibly achieve more certainty with U.S. revenues (not sure what that would look like), then a BP has a whole lot more to work with.
Oh, and with regards to "Enterprise Value", you would include A/P in the debt number (short term debt). But EV is really just a calculation. It doesn't represent a BO estimate.