The question is well covered by the expression in the TV show, what would you do.
If you're suffering with a cancer and the best thing being offered is CAR-T, but the risk is a future cancer, what would you do.
Sadly we're learning that we really can't know all the long term side effects of all sorts of things we eat, drink, etc. all the time. Some things are rather predictable, like smoking, but others certainly are not. The Covid vaccines no doubt saved millions of lives, but a few may have died from it. Herceptin, and other drugs like Kadcyla developed from it, has been a miracle worker in Her 2 positive breast cancer, but a allergic reaction in a tiny percentage has been deadly.
I believe our vaccine will be found to have virtually no substantial negative side effects, but if applied to millions, if even one passed on shortly after receiving it, it would be suspect unless something else was found that caused the death.
As long as a patient has choices they may not choose CAR-T, but if nothing else offers possibilities, death is the other choice. Some people do choose death over the treatment that sustains their lives, especially when the likelihood of a cure is approaching zero. At this point, no one really knows if in any given patient our vaccine could result in a cure.
In 1994 my wife was being treated for breast cancer with chemo after surgery. She met a gentleman who was given less than 3 months to live with treatment. He and his wife had always wanted to see parts of South America, and his Drs. agreed to a 2 week vacation there provided he take treatment just before leaving, and immediately on return. When he returned, no cancer could be found. I have no idea if his remission was sustained, but believe he lived far longer the 3 months. I don't know if our vaccine could cause such miracles in some patients and we'll really never know until it's tried in millions of patients.
Quality of life often fails to get enough attention, it should be one of the biggest reasons to consider our vaccine. It's rare that a cancer therapeutic not be accompanied with negative quality of life issues, this appears to be the case with our vaccine. Certainly it probably will require others with side effects to achieve big benefits, but the side effects are still far less than SOC treatment, as I understand it.
Gary
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