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Biowatch

04/17/24 4:45 PM

#251486 RE: DewDiligence #251485

How_Much_Does Weight Loss_Help_with Sleep Apnea?

https://www.healthline.com/health/sleep-apnea/sleep-apnea-weight-loss

Weight loss tends to reduce problems with sleep apnea (and snoring,) so I’m not sure how you can disentangle the two questions.

I.e., which came first, the chicken or the egg? If weight loss reduces sleep apnea, and weight loss drugs reduce weight, are they specifically reducing sleep apnea or is that a beneficial side effect?

Doc328

04/17/24 5:09 PM

#251489 RE: DewDiligence #251485

I believe its entirely or almost entirely due to the actual weight loss. The same phenomenon was seen in the bariatric surgery literature with similar results and seen across the board for different surgical techniques (slight exception with Lap Band showing less weight loss and less AHI reduction). Blinding is of course difficult with bariatric surgery and many of these are uncontrolled studies. Other weight loss drugs have also seen good OSA data. Though results were pretty much a foregone conclusion, the main positive for the GLP-1's is that this data will help to get insurance to cover patients who do not have DM/hyperglycemia

Here's a review
https://www.sciencedirect.com/science/article/pii/S217351151630046X?via%3Dihub