It takes a lot of energy to run desalinization plants. And ones being planned in Cali have to deal with outflows of hyper or much more salient water back into the ocean deeper water areas, but there are a lot of ecological issues to consider. So that may be a partial solution for more human water needs versus massive industrial water needs. No magic bullet; I believe where they site these plants geographically (near abundant water resources) is the smartest solution in the near term.
There’s a proposed project now to pump desalinated water from mexico to arizona, but there are numerous issues with the pipeline route - environmental, land rights etc.
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