It's at the top of the list of one of the most understood mechanism of action treatments in this class of treatment. There is no other modality, which has enjoyed the same amount of observational studies, and over as long a period. There have been innumerable treatment modalities approved, not only for a meager two months mOs improvement, but also, where the mechanism of action is yet to be fully understood. Despite the serious adverse events caused by many existing treatments, I'm surprised we don't have more vocal advocacy groups raising questions.