I'm not one to defend Missling these days but he really didn't have much choice other than (1) just sell the company for a pittance and close up shop or (2) pivot to 3-71 for Schizophrenia and hope he could somehow get additional financing down the road if Phase II results were very promising. A path for regulatory advancement of 2-73 for Rett is totally an unanswered question so Missling had no bet to place on that. The frank truth is that Missling pretty much has to obtain AD regulatory approval in Europe or the U.S. to be assured of keeping AVXL's doors open.