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nidan7500

03/20/24 8:02 PM

#454596 RE: Hosai #454580

Hosai, your response is very much appreciated . We get the concepts of Top Management responsibility of course since many investors here have been in such positions themselves. Top managements responsibilities include Listening to and responding to all feedback , that is not is not always fun, but it comes w/the turf. Most investors here are well informed, particularly in BIO and we are also aware of the risks. We GET IT.

The feedback being given is not critical of any individuals strategic styles. Many may point out they do not expect daily updates or routine feedback however effectively dealing with and developing a credible and timely communication system is elementary. Extended periods of silence will not work. Shareholders may support the entire AVXL team and the work being done. We do not expect scheduled clinical-Bio breakthroughs .

I think most AVXL investors understand that the future will hold both good days and slow or NOT good days. We do not need hand holding but we do require and expect credible, periodic news from designated management who understand that such is also part of their communication responsibility.