Small sample size. Management likes underpowering trials to delay everything with need of larger trials down the road. Keeps them collecting those juicy checks and free options.
Another huge and meaningful trial that will give solid insights into Misslings modus operandi, if nothing else. And it splits that huge n between placebo and drug in two parts, so the results will be very malleable lending itself to all sorts of cool post hoc analysis and wonderful conclusions to carry on from.
Misleading's shenanigan continues. Karuna therapeutics had 182 patient in their phase2 trial, but penny pincher Misleading runs trial with 40 patient, it will take him 3-4year to recruit 40 patient.