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03/13/24 3:44 PM

#678364 RE: GermanCol #678361

GermanCol,

I appreciate your effort at this because as you know, I once suggested that there might have been a stealth crossover by SOC to treatment which would have had to remain very quiet. Lykiri assured me this did not happen so your analysis of the sensors kind of hits home with me about what might have really happened. Bottom line is that some patients were purposely left out of all of the published data and analysis to date and more of an explanation is to be expected at some point. Again, I appreciate your attempt to interpret this. Best wishes.

meirluc

03/13/24 9:22 PM

#678428 RE: GermanCol #678361

German col, it is hard for me to wrap my head around
the problem as to how the group of 35 (that were distinct
from the group of 64 crossovers) were divided up.
From Dr. Liau's Q&A period I got the impression that there
were 6-7 LTFU in that group and she did not specify whether
any of them were Pseudos who crossed over. That leaves
about 28-29 patients of whom you say many of them were
Pseudos who crossed over ( censored) and that leaves some poor OS
performing patients who were permanent placebos

We really need more information about those 35 patients although
it looks to me that none of those 35 can contribute anything statistically
to this trial.