One more reason NWBO is worth more than $10/sh today at this pre-approval stage. 2024 is the year the medical establishment and patients will realize a new entrant (DCVax) in treating GBM cancer may have actually broken the code to curing cancer across the board. It is not a matter of $10/sh or not; it will be a matter of PRICE DISCOVERY. Here’s my layman’s reasoning why.
DCVax’s mechanism of action leverages the immune system and therefore is intuitive to doctors A. All antigens, information - DCVax uses actual tumor lysate and importantly presents hundreds of DIFFERENT tumor antigens to the immune system - Other drugs don’t
B. Efficacy, holistic approach - Diversity in weapons: T cells, B cells, and antibodies - Diversity in targets: activates unique cytotoxic T cells, helper T cells, B cells, and antibodies to target each different tumor antigen - Robust immune memory: after killing the cancer, some T cells and B cells will become immune memory cells and remain - Other drugs don’t
C. Naturally is not toxic - Immature T cells and B cells travel thru the thymus and spleen. This process naturally screens out and destroys the self-reactive (autoimmune, toxicity) immune cells. - Other drugs don't
D. Renaissance in how cancer is treated - Today doctors have a “drug” that does not cure and must balance efficacy against toxicity - Tomorrow doctors will have a DCVax “vaccine”, so their focus can then include optimizing a total therapy, including quality of life
The prospect of cancer cure is what all cancer patients desire most A. DCVax as a vaccine - Creating a more robust immune memory equates to cure and prevention - Highly efficacious, non-toxic profile - Other drugs are not
B. DCVax may possibly vaccinate against Second Primary Cancers - 19% of cancer patients get a second cancer sometime in their life (unrelated to their first cancer). https://pubmed.ncbi.nlm.nih.gov/24857148/ - Dr. Bosch made this interesting point. Many of the tumor antigens found on the GBM tumor lysate were also the same tumor antigens found in other cancers - Hypothesis is a DCVax enhanced immune memory can protect against other cancers, especially for those with genetic or family predisposition to a certain cancer. - Other drugs don't