I think it will be helpful in the overall package, but the main endpoints will be most important. Hopefully as Missling intimated at Cowen the SAP supports the order they will be served.
There is a very specific procedure the FDA has for getting biomarkers accepted as surrogate endpoints. That is, those used in accelerated applications. If the Ab ratio is not accepted an surrogate endpoint the the trial has to be evaluated on the pre defined endpoint.
The improved Ab ratio will be considered as supporting evidence but not in place of the defined endpoints.