At first, considering label expansion in late December 2019, the Total OpEx of over 500m could be understood as the CVD indication being rolled out. But, really, the DuDisaster happened on March 31, and although Generics didn't enter the market at that point (only months later) it is clear that JT and the gang did not act as they should have wrt conserving cash. Still remember how shellshocked JT sounded the day after. Heck even 2021 had a huge OpEx when Generics had well entered the game.
Thanks for your graphs.