With regard to communication and audience interpretation I felt that the answers provide more doubt that there will be an RSV phase III trial…
I did not get any vibes that anything has changed. The RSV programs will progress to phase-3, in the pediatric and/or adult populations, if the phase-2 data warrant advancing the programs. One analyst asked whether weak phase-2 data from the adult trial would preclude advancing the pediatric program, and the answer was no — each program stands on its own merits.
While the peds RSV population may be considered more naive than the COVID phase 2 population it is striking that the answers from Enanta indicate that in the RSV peds study virology readouts are key vs symptoms.
It make be striking to you, but it makes perfect sense when dealing with a naive population for RSV vs a population which most people had previous infections like for Covid.