Replies to post #450907 on Anavex Life Sciences Corp (AVXL)

[Joseph_K]

blarcamesine reduces brain shrinkage, and, unless I am mistaken, mAb's tend to accelerate that process

You are not mistaken. See, for example, this article:
"Brains Shrink With Anti-Amyloid Alzheimer's Drugs
— Treatments accelerate brain atrophy, but reasons why remain a mystery"
https://www.medpagetoday.com/neurology/alzheimersdisease/103817

ARIA-inducing monoclonal antibodies had variable effects on whole brain volume. Donanemab (mean difference -4.6 mL, 95% CI -7.6 to -1.6; +23% relative to change in placebo) and lecanemab (mean difference -5.2 mL, 95% CI -8.1 to -2.4; +36.4% relative to change in placebo) showed accelerated whole brain volume loss, but aducanumab and bapineuzumab did not.