Replies to post #450570 on Anavex Life Sciences Corp (AVXL)

[boi568]

I imagine if I thought blarcamesine was no better than donepezil I also wouldn't think much of its chances.

[JKS3]

I think the estimated expenses for an AD P3 (>800 subjects) and a Rett P3 are quite conservative. My estimate would be $150 M minimum for the trials alone. The number of objects may need to be higher (the P2/3 of 500 subject did not reach statistical significance for approval). The way Missling runs the company, I put the chances of approval for 273 within 6 years for anything at zero.
As for 3-71, see you in a decade if Anavex still exists.

[Investor2014]

But Falconer, Mayo and many more less 'qualified' posters said WGT and they even calculated how rich I would be?

[rayovac812]

After several trials with A273 that imply mild benefit without offering definite proof of that benefit

Not a well considered opinion.

How does anyone consider doing the opposite of acceleration of brain volume loss, with definite proof given...a mild benefit?

Other answers/drugs include acceleration of brain volume loss. I suppose this is what the doctor would recommend? Come on.

Reduction or arrest of brain volume loss, is a considerable benefit. I can consider any justification for your thinking, but I have yet to see any.

[WolfofMia]

Your 1% chance of approval is a good as Leos chance of not overpaying for his new house LMAO!

Or even better of Investor not trying to spin truth to fit his own agenda.

At least you put lots of effort in your distortion! Kudos!!

They must pay better where you came from.

[LakeshoreLeo1953]

Doc, I apologize for citing the logic of your post so that the class clown
commented to you.
Can't imagine it is anything other than water off a duck's back.

[XenaLives]

A system that approves crap because of the influence of "capital".....

https://www.aarp.org/health/drugs-supplements/info-2024/aduhelm-alzheimers-drug-taken-off-market.html

6 Aduhelm Side Effects You Should Know About

Key takeaways:

Aduhelm (aducanumab) is an Alzheimer’s disease medication that’s given monthly as an infusion into your vein. It’s the first medication to target the underlying cause of Alzheimer’s disease.

The most common Aduhelm side effects are swelling and small bleeds in the brain. They often don’t cause noticeable symptoms, so your healthcare provider will likely order regular brain scans to look for these problems.

Other possible Aduhelm side effects include headaches, confusion, and nausea.

https://www.goodrx.com/aduhelm/aduhelm-side-effects

But fails to approve a drug that presents ANY statically positive benefit absent those or any other side effects is totally messed up.