I largely agree with your post, including your skepticism (which is properly hedged IMO) and your "belief ... that now is not the time to sell out a position in AVXL" and your "belief that the AVXL platform will [probably] eventually reward investors." I added "probably," but I don't think that changes what you meant. :) Yes, it's a crapshoot, but a pretty good (but not WGT!) one.
My selling when I did was far from brilliant, but I'd had two other large holdings surprisingly suffer major drops and I felt on the precipice of too much loss all around; and I really was overinvested in AVXL. I still have enough to make me rich if its pipeline does as well as I hope.