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Replies to post #448875 on Anavex Life Sciences Corp (AVXL)
bas2020
01/23/24 11:36 AM
#448878 RE: BIOChecker4 #448875
• Odds Ratio of ADAS-Cog meaningful improvement in cognition at threshold of -0.5 points or less (90% CI) 1.839 (1.17, 2.94) P = 0.015 • Odds Ratio of ADCS-ADL meaningful improvement in function at threshold of +3.5 points or higher (90% CI) 2.67 (1.17, 6.13) P = 0.0255 • ANAVEX®2-73 treatment slowed cognitive decline by 45% compared to placebo at 48 weeks • Mean difference in ADAS-Cog score change of -1.85 points • Compared to placebo, ANAVEX®2-73 (blarcamesine) reduced clinical decline of cognition and function by 27% with mean score difference of -0.42 points (p=0.040) as measured by CDR-SB • ADCS-Cog and CDR-SB (p < .025) proving further significance of stat. sig. improvements and trial success. • Identification of two key biomarkers (Aß42/40 ratio and brain volume stabilization) for AA pathway option.